FOLIC ACID RESTRICTS SARS-COV-2 INVASION BY METHYLATING ACE2

Folic acid restricts SARS-CoV-2 invasion by methylating ACE2

The current COVID-19 pandemic is motivating us to dish elucidate the molecular mechanism of SARS-CoV-2 invasion and find methods for decreasing its transmissibility.We found that SARS-CoV-2 could increase the protein level of ACE2 in mice.Folic acid and 5-10-methylenetetrahydrofolate reductase (MTHFR) could promote the methylation of the ACE2 promo

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Knowledge Sharing as a Central Idea of Open Science and NDT 4.0

NDT 4.0 has become a buzz word in the world of NDT in recent years.At the same time, terms like open science, open access or open peer review cross our ways regularly and define present and future concepts to advance knowledge sharing in society.This article brings the concept of open science and NDT 4.0 together.While knowledge sharing as part of

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Intranasal delivery of a chimpanzee adenovirus vector expressing a pre-fusion spike (BV-AdCoV-1) protects golden Syrian hamsters against SARS-CoV-2 infection

We evaluated the immunogenicity and protective ability of a chimpanzee replication-deficient adenovirus vectored COVID-19 vaccine (BV-AdCoV-1) expressing a stabilized pre-fusion SARS-CoV-2 spike glycoprotein in golden Syrian hamsters.Intranasal administration of BV-AdCoV-1 elicited strong humoral and cellular immunity in the animals.Furthermore, va

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